Cancun is considered the Spring Break capital of the world, and is known for its beaches, numerous resorts and energetic nightlife. There are 2 distinct areas: the more traditional downtown area, El Centro, and Zona Hotelera, a long, beachfront strip of high-rise hotels, nightclubs, shops and restaurants. During spring break period (February to April), digital nomads can easily avoid college spring breakers by renting apartments and avoiding cheap resorts.
Cancun is often thought of as expensive, however it is possible to live cheaply in Cancun. As a general rule, you can rent a studio apartment for between $300 and $400 USD per month, and it is cheaper to rent an accomodation in Centro than in Zona Hotelera. While Cancun might not be the most affordable place in Mexico, there are a lot of pros to living here, such as access to an international airport, a fairly English-friendly place and good infrastructure for foreigners.
Cancun is considered to be safer than any major American city, especially when you stick to the hotel zone and Centro. It would still serve you well to make sure you are not walking on quiet streets alone late at night, but as long as you are in the centre where locals and tourists gather, you will feel safe. Women digital nomads should note that within the hotel zone and Centro, there is a separate tourism police force that provides multilingual support. It is recommended to take taxis from a 'sitio' or by calling a radio taxi, and many hotels will be able to help you with this.
If you want Cancun to yourself, avoid the peak season that runs from December to April and July to August. September to November are prone to heavy storms — this region faces the worst threat for hurricanes in the fall.